Found: The dial in the brain that controls the immune system

https://www.nature.com/articles/d41586-024-01259-2

Scientists have long known that the brain plays a part in the immune system — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense immune cues from the periphery of the body and act as master regulators of the body’s inflammatory response.

doi: https://doi.org/10.1038/d41586-024-01259-2

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"title": "Found: the dial in the brain that controls the immune system",
"description": "Scientists have long known that the brain plays a part in the immune system — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense immune cues from the...",
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"content": "<div>\n <article>\n <div>\n <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n <div><h2 id=\"Bib1\">References</h2></div>\n <h2>Related Articles</h2>\n <ul>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n Your brain could be controlling how sick you get — and how you recover\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n Guardians of the brain: how a special immune system protects our grey matter\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n Can autoimmune diseases be cured? Scientists see hope at last\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n Anxiety can be created by the body, mouse heart study suggests\n </a>\n </p>\n </li>\n </ul>\n <h2 id=\"subjects\">Subjects</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n </li>\n</ul>\n <section>\n <h2 id=\"tablist-heading\">Latest on:</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-0-container\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-1-container\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-2-container\">Neuroscience</a>\n </li>\n </ul>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-03158-0\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-03158-0/d41586-026-03158-0_53800296.jpg\" />\n <p>Chimp and gorilla brains resist weight loss with age — unlike human brains</p>\n <p><span>Research Highlight</span> <span>09 OCT 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-03132-w\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-03132-w/d41586-026-03132-w_53780934.jpg\" />\n <p>Can your brain grow new neurons? 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How researchers are solving a century-old puzzle</p>\n <p><span>News Feature</span> <span>07 OCT 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n</section>\n <div>\n <div>\n <h2>\n <img src=\"https://www.nature.com/static/images/logos/nature-careers-logo-3c89275050.svg\" alt=\"Nature Careers\" />\n </h2>\n </div>\n <h3>\n <a target=\"_blank\" href=\"https://www.nature.com/naturecareers/\">Jobs\n </a>\n </h3>\n <ul>\n <li>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/0cbac729-18c4-4ffc-a399-1725cb26824b/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12865588/associate-or-senior-editor-bmc-nursing/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Associate or Senior Editor, BMC Nursing</a></h4>\n <div>\n <p>Job Title:    Associate or Senior Editor, BMC Nursing Location:   Shanghai or Pune – hybrid working model Application Deadline: 30th October 2026  ...</p>\n <p>Shanghai or Pune – hybrid working model</p>\n <p>Springer Nature Ltd</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/121465b9-8274-400b-b7a9-ebfcc5a13127/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12865587/associate-or-senior-editor-bmc-psychology/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Associate or Senior Editor, BMC Psychology</a></h4>\n <div>\n <p>Job Title:    Associate or Senior Editor, BMC Psychology Location:   Shanghai or London – hybrid working model Application Deadline: 30th October, ...</p>\n <p>Shanghai or London – hybrid working model</p>\n <p>Springer Nature Ltd</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/121465b9-8274-400b-b7a9-ebfcc5a13127/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12865586/publisher-or-senior-publisher/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Publisher or Senior Publisher</a></h4>\n <div>\n <p>Job Title: Publisher or Senior Publisher Location: Beijing or Shanghai - Hybrid Working Model Application Deadline: 25th October 2026       About S...</p>\n <p>Beijing or Shanghai - Hybrid Working Model</p>\n <p>Springer Nature Ltd</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/121465b9-8274-400b-b7a9-ebfcc5a13127/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12858264/global-recruitment-of-outstanding-young-talents/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Global Recruitment of Outstanding Young Talents</a></h4>\n <div>\n <p>We are seeking exceptional candidates who qualify for the National Science Fund for Excellent Young Scholars (Overseas)</p>\n <p>1068 Xueyuan Avenue, Shenzhen 518055 P. 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